The human tumor microbiome is composed of tumor type-specific intracellular bacteria
| Autor: | Adina Weinberger, Ron Shaoul, Morgan G. I. Langille, Alexandria P. Cogdill, Giuseppe Mallel, Talia Golan, Anat Ronai, Arnon Meltser, Vancheswaran Gopalakrishnan, Christian U. Blank, Jennifer A. Wargo, Einav Yehuda-Shnaidman, Tali Dadosh, Maya Dadiani, Daniel S. Peeper, Merav Rokah, Alon Ben-Nun, Reetakshi Arora, Elinor Gigi, Aviram Nissan, Keren Levanon, Zachary A. Cooper, Tatiana Dorfman, Gavin M. Douglas, Iris Kamer, Gabriel Ologun, Ilana Livyatan, Zvi R. Cohen, Iris Barshack, Noam Shental, Elisa A. Rozeman, Nicola Baldini, Einav Nili Gal-Yam, Nancy Gavert, Shlomit Yust-Katz, Ran Kremer, Eran Segal, Ravid Straussman, Roi Weiser, Yaara Zwang, Yuval Bussi, Hagit Shapira, Tehila Atlan, Dan J. Raz, Amnon Amit, Smadar Levin-Zaidman, Bella Kaufman, Aviva Rotter-Maskowitz, Keren Bahar-Shany, Tali Siegal, Abdul Wadud Khan, Judith Sandbank, Deborah Nejman, Gili Perry, Jair Bar, Maya Lotan-Pompan, Sofia Avnet, Ofra Golani, Garold Fuks, Leore T. Geller, Sagi Harnof |
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| Přispěvatelé: | Nejman D., Livyatan I., Fuks G., Gavert N., Zwang Y., Geller L.T., Rotter-Maskowitz A., Weiser R., Mallel G., Gigi E., Meltser A., Douglas G.M., Kamer I., Gopalakrishnan V., Dadosh T., Levin-Zaidman S., Avnet S., Atlan T., Cooper Z.A., Arora R., Cogdill A.P., Khan M.A.W., Ologun G., Bussi Y., Weinberger A., Lotan-Pompan M., Golani O., Perry G., Rokah M., Bahar-Shany K., Rozeman E.A., Blank C.U., Ronai A., Shaoul R., Amit A., Dorfman T., Kremer R., Cohen Z.R., Harnof S., Siegal T., Yehuda-Shnaidman E., Gal-Yam E.N., Shapira H., Baldini N., Langille M.G.I., Ben-Nun A., Kaufman B., Nissan A., Golan T., Dadiani M., Levanon K., Bar J., Yust S., Barshack I., Peeper D.S., Raz D.J., Segal E., Wargo J.A., Sandbank J., Shental N., Straussman R. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Colon Macrophage medicine.medical_treatment Biology 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer RNA Ribosomal 16S medicine Microbiome Breast Lung Multidisciplinary Bacteria Melanoma Intracellular parasite Microbiota Ovary Cancer Immunotherapy medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Neoplasm Female Pancreas Human |
| Zdroj: | Science |
| Popis: | Profiling tumor bacteria Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al. produced an exhaustive catalog of the bacteria present in more than 1500 human tumors representing seven different tumor types (see the Perspective by Atreya and Turnbaugh). They found that the bacteria within tumors were localized within both cancer cells and immune cells and that the bacterial composition varied according to tumor type. Certain biologically plausible associations were identified. For example, breast cancer subtypes characterized by increased oxidative stress were enriched in bacteria that produce mycothiol, which can detoxify reactive oxygen species. Science , this issue p. 973 ; see also p. 938 |
| Databáze: | OpenAIRE |
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