Association between lower serum vitamin D (25-hydroxy-cholecalciferol) concentrations and cognitive impairment in older adults: data from a populational-based cohort study in a middle-income country
| Autor: | Claudia Soar, Júlia Dubois Moreira, Eleonora d'Orsi, Susana Cararo Confortin, Gilciane Ceolin, André Junqueira Xavier, Luísa Harumi Matsuo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Medicine (miscellaneous) Logistic regression Middle income country Cohort Studies chemistry.chemical_compound Internal medicine Vitamin D and neurology Humans Medicine Cognitive Dysfunction Vitamin D Cognitive impairment Aged Calcifediol Serum vitamin Nutrition and Dietetics business.industry Public Health Environmental and Occupational Health Vitamins Vitamin D Deficiency Cross-Sectional Studies chemistry Quartile Female Cholecalciferol business Cohort study |
| Zdroj: | Public Health Nutrition. 25:2507-2516 |
| ISSN: | 1475-2727 1368-9800 |
| Popis: | Objective:To investigate the association between serum vitamin D (25-hydroxy-cholecalciferol) (25(OH)D) concentrations and cognitive impairment in older adults living in Southern Brazil.Design:Cross-sectional analysis using data from the second follow-up wave of the populational-based EpiFloripa Aging Cohort Study was collected in 2013–2014.Setting:Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE). Blood samples were collected to measure serum vitamin D concentrations using a chemiluminescent microparticle immunoassay. Vitamin D concentrations were distributed in quartiles (Q1: 4·0–20·7 ng/ml; Q2: 20·8–26·6 ng/ml; Q3: 26·7–32·0 ng/ml and Q4: 32·1–60·1 ng/ml), and its association with cognitive impairment was tested by crude and adjusted logistic regression (sociodemographic, behavioural and health aspects) using Q4 as a reference group.Participants:200 men and 371 women aged 60 years or older participated in this study.Results:The prevalence of probable cognitive impairment was 21·7 %. Those without cognitive impairment had a higher mean of vitamin D serum concentrations (26·8 v. 24·6, P = 0·014). In the crude analysis, only individuals in Q2 of vitamin D presented an increased risk for probable cognitive impairment compared with Q4 (highest quartile) (OR 2·65, 95 % CI 1·46, 4·81), remaining significant in the adjusted analysis (OR 6·04, 95 % CI 2·78, 13·13). While Q1 (lowest quartile) was not associated in the crude analysis, but when adjusted, an increased risk of cognitive impairment was observed.Conclusion:The lowest quartile of vitamin D was directly associated with probable cognitive impairment in older adults in Southern Brazil. More studies are needed to investigate whether maintaining adequate serum levels may represent a significant factor in preventing age-related neurological disorders as well as to verify the need for new cutoff points for this age group. |
| Databáze: | OpenAIRE |
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