Current advances in in vitro models of central nervous system trauma
| Autor: | Bonnie L. Firestein, Anton Omelchenko, Nisha K. Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Traumatic brain injury business.industry Central nervous system Biomedical Engineering Medicine (miscellaneous) Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease Article Cns injury Biomaterials 03 medical and health sciences medicine.anatomical_structure medicine 0210 nano-technology business Neuroscience Spinal cord injury 030304 developmental biology |
| Zdroj: | Curr Opin Biomed Eng |
| Popis: | CNS trauma is a prominent cause of mortality and morbidity, and although much effort has focused on developing treatments for CNS trauma-related pathologies, little progress has been made. Pre-clinical models of TBI and SCI suffer from significant drawbacks, which result in substantial failures during clinical translation of promising pre-clinical therapies. Here, we review recent advances made in the development of in vitro models of CNS trauma, the promises and drawbacks of current in vitro CNS injury models, and the attributes necessary for future models to accurately mimic the trauma microenvironment and facilitate CNS trauma drug discovery. The goal is to provide insight for the development of future CNS injury models and to aid researchers in selecting effective models for pre-clinical research of trauma therapeutics. |
| Databáze: | OpenAIRE |
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