Constituents of Eugenia sandwicensis with potential cancer chemopreventive activity
| Autor: | Eun Jung Park, Michael E. Hawthorne, Rajendra G. Mehta, A. Douglas Kinghorn, Norman R. Farnsworth, Jian-Qiao Gu, Lumonadio Luyengi, John M. Pezzuto |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Antioxidant Coumaric Acids Eugenia sandwicensis 9 10-Dimethyl-1 2-benzanthracene medicine.medical_treatment Molecular Conformation Plant Science Spectrometry Mass Fast Atom Bombardment Horticulture Biology Organ culture Biochemistry Biological Factors Mice chemistry.chemical_compound Tissue culture Mammary Glands Animal Organ Culture Techniques Triterpene medicine Animals Anticarcinogenic Agents Gallic acid Molecular Biology chemistry.chemical_classification Mice Inbred BALB C Plants Medicinal Plant Stems Biological activity General Medicine Boraginaceae biology.organism_classification Terpenoid chemistry Female |
| Zdroj: | Phytochemistry. 58:121-127 |
| ISSN: | 0031-9422 |
| Popis: | A triterpenoid, 3β- cis - p -coumaroyloxy-2α,23-dihydroxyolean-12-en-28-oic acid ( 1 ), and two natural products, 3β- trans - p -coumaroyloxy-2α,23-dihydroxyolean-12-en-28-oic acid ( 2 ) and 23- trans - p -coumaroyloxy-2α,3β-dihydroxyolean-12-en-28-oic acid ( 3 ), were isolated from a chloroform-soluble extract of the stems of Eugenia sandwicensis , along with 10 known compounds. Of these compounds, 2 showed significant inhibitory activity (79.2% at 4 μg/ml) in a 7,12-dimethylbenz[ a ]anthracene-induced mouse mammary organ culture assay system of relevance to cancer chemoprevention. Gallic acid was isolated as an antioxidative constituent of an ethyl acetate-soluble extract of E. sandwicensis stems. Isolates 1 – 3 were characterized on the basis of spectral and chemical evidence. |
| Databáze: | OpenAIRE |
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