Grey Matter Density Predicts the Improvement of Naming Abilities After tDCS Intervention in Agrammatic Variant of Primary Progressive Aphasia

Autor: Rosa Manenti, Roberto Gasparotti, Alessandro Padovani, Orazio Zanetti, Barbara Borroni, Michela Petesi, Enrico Premi, Donata Paternicò, Maura Cosseddu, Maria Cotelli, Michela Brambilla
Rok vydání: 2016
Předmět:
Male
Neurology
Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA
medicine.medical_treatment
Neuropsychological Tests
Audiology
Transcranial Direct Current Stimulation
tDCS
Primary progressive aphasia
0302 clinical medicine
Gray Matter
Language
Brain Mapping
Rehabilitation
Radiological and Ultrasound Technology
Transcranial direct-current stimulation
05 social sciences
Neuropsychology
Brain
Organ Size
Middle Aged
Prognosis
Magnetic Resonance Imaging
Temporal Lobe
medicine.anatomical_structure
Female
Anatomy
Psychology
Frontotemporal dementia
MRI
Cognitive psychology
medicine.medical_specialty
Primary Progressive
Grey matter
050105 experimental psychology
Treatment
Voxel-based morphometry
Aged
Aphasia
Primary Progressive
Humans
Language Therapy
03 medical and health sciences
Aphasia
medicine
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
medicine.disease
Neurology (clinical)
030217 neurology & neurosurgery
Zdroj: Europe PubMed Central
ISSN: 1573-6792
0896-0267
Popis: Agrammatic variant primary progressive aphasia is a neurodegenerative disorder specifically characterized by language deficits. A recent study has demonstrated a beneficial effect of transcranial direct current stimulation (tDCS) in combination with language training on naming accuracy in these patients. The aim of the study was to evaluate whether the improvement of naming accuracy after tDCS during language training was related to regional grey matter (GM) density. Eighteen avPPA patients underwent a brain magnetic resonance imaging before receiving a treatment that consisted of tDCS over the left dorsolateral prefrontal cortex during individualized language training (10 daily therapy sessions, 5 days per week from Monday to Friday). Performances on neuropsychological tests and naming of objects (treated and untreated) and actions were assessed at baseline, post-treatment and 3 months after treatment. Correlations between individual changes after treatment on neuropsychological tests and on picture naming task and voxel-based GM volume at baseline were performed. We found that the improvement in the naming of treated objects was positively correlated with GM volume in the left fusiform, left middle temporal, and right inferior temporal gyri whereas action naming change was related to GM density in the left middle temporal gyrus. In conclusion baseline density of GM in these brain regions was associated with greater treatment response on naming performances, suggesting that intervention in early disease stages might be most successful. These findings have implication for designing future rehabilitation protocols in language variants of frontotemporal dementia.
Databáze: OpenAIRE
Externí odkaz: