Prevalence of rheumatoid arthritis in the French West Indies: Results of the EPPPRA study in Martinique
| Autor: | Christophe Deligny, Lauren Brunier, Serge Arfi, Marie Bleterry, Katlyn Polomat, Michel De Bandt, Sylvie Merle, Véronique Dehlinger, G. Jean-Baptiste, Christian Derancourt, Rishika Banydeen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Veterinary medicine medicine.medical_specialty Adolescent Population Arthritis Rheumatoid Very frequent Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Epidemiology Prevalence medicine Humans Martinique 030212 general & internal medicine education Aged Aged 80 and over 030203 arthritis & rheumatology education.field_of_study business.industry Middle Aged medicine.disease Regimen Rheumatoid arthritis Female business Rheumatism |
| Zdroj: | Joint Bone Spine. 84:455-461 |
| ISSN: | 1297-319X |
| DOI: | 10.1016/j.jbspin.2016.09.003 |
| Popis: | Objectives Studies suggest that rheumatoid arthritis (RA) is less frequent in African populations. However, no recent precise data exists for Afro-Caribbeans. The EPPPRA project is a prospective epidemiological survey to describe prevalence and clinical aspects of RA in the French West Indies (Martinique, Guadeloupe, French Guiana). Methods EPPPRA involved all rheumatologists from the French West Indies who included all patients with a known clinical diagnosis of RA, during a one-year period. We outline here results for Martinique. Results EPPPRA estimated an overall world age-standardized prevalence of RA at 0.10% [95% CI 0.09% to 0.11%] in Martinique, with a high female predominance (88.1%) and 93.1% of self-reported Afro-Caribbeans. Mean age at diagnosis was 49.6 ± 16.0 years. A majority of subjects presented at least 4 criteria points from the 1987 American College of Rheumatology (ACR) classification (94.4%) and at least 6 points (78.2%) from the 2010 ACR/European League Against Rheumatism (EULAR) classification. A high immune seropositivity rate was highlighted (84.2%). Despite functional impact observed in 40.5% of patients, 71.4% presented a low disease activity level. Methotrexate was the most common ongoing treatment (73%), followed by biotherapies (24.4%). Numerous patients (68.6%) received a steroid regimen. Cardiovascular risk factors were very frequent, contrasting with a very low tobacco use (8.7%), Conclusion This work outlines low standardized prevalence of RA in a French Afro-Caribbean population with specific characteristics (high female predominance, high immune seropositivity, low tobacco use). Despite easy access to care and biotherapies, approximately half of RA patients still present destructive disease with functional impact. |
| Databáze: | OpenAIRE |
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