Differential correlations between inflammatory cytokines and psychopathology in veterans with schizophrenia: potential role for IL-17 pathway
Autor: | Shuko Lee, Consuelo Walss-Bass, Dimitre H. Dimitrov, Nicole Braida, Jesse Yantis, Celina Valdez, Dawn I. Velligan, R. Madelaine Paredes |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male Chemokine Psychosis Statistics as Topic Inflammation Proinflammatory cytokine medicine Humans Biological Psychiatry Veterans Psychiatric Status Rating Scales biology Psychopathology Interleukin-17 Middle Aged medicine.disease Psychiatry and Mental health Schizophrenia Immunology biology.protein Cytokines Female Interleukin 17 medicine.symptom Psychology Clinical psychology Diagnosis of schizophrenia Signal Transduction |
Zdroj: | Schizophrenia research. 151(1-3) |
ISSN: | 1573-2509 |
Popis: | Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological parameters in patients with schizophrenia. We hypothesized that severity of symptoms would correlate with increased levels of inflammatory cytokines. Serum samples from 47 veterans with a diagnosis of schizophrenia and 20 healthy controls were tested for levels of 38 cytokines/chemokines involved in regulation of immune/inflammatory reactions using a Millipore multiplex bead array in a Luminex 100 system. We found significantly increased levels of GRO, MCP-1, MDC, and sCD40L, and significantly decreased levels of IFN-γ, IL-2, IL-12p70, and IL-17, in schizophrenia patients compared to controls. In addition, we observed positive correlations between levels of cytokines and the Positive and Negative Symptoms Scale (PANSS) scores in subjects with schizophrenia for G-CSF, IL-1β, IL1ra, IL-3, IL-6, IL-9, IL-10, sCD40L and TNF-β. Pathway analyses showed these cytokines to be part of the IL17 pathway. Using principal component analyses, we found the factor that included these cytokines and IL-17 to be associated with positive, general and total PANSS scores. These results suggest that alterations in this pathway may play a role in development of psychotic symptoms in schizophrenia. |
Databáze: | OpenAIRE |
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