The Value of Arterial Spin-Labeled Perfusion Imaging in Acute Ischemic Stroke
| Autor: | Samuel Hou, Jeffrey L. Saver, Rana Fiaz, Qing Hao, Jeffry R. Alger, Joe X Qiao, Danny J.J. Wang, Noriko Salamon, Whitney B. Pope, Matthias Gunther, David S Liebeskind |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Contrast Media Perfusion scanning Article Magnetic resonance angiography Brain Ischemia Brain ischemia otorhinolaryngologic diseases medicine Humans Stroke Aged Neuroradiology Aged 80 and over Advanced and Specialized Nursing medicine.diagnostic_test business.industry medicine.disease Radiography Cerebral blood flow Cerebrovascular Circulation Female Spin Labels Neurology (clinical) Radiology Cardiology and Cardiovascular Medicine Nuclear medicine business Perfusion Blood Flow Velocity Magnetic Resonance Angiography |
| Zdroj: | Stroke. 43:1018-1024 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.111.631929 |
| Popis: | Background and Purpose— The purpose of this study was to evaluate the potential clinical value of arterial spin-labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) through comparison with dynamic susceptibility contrast (DSC) enhanced perfusion MRI. Methods— Pseudocontinuous ASL with 3-dimensional background-suppressed gradient and spin echo readout was applied with DSC perfusion MRI on 26 patients with AIS. ASL cerebral blood flow and multiparametric DSC perfusion maps were rated for image quality and lesion severity/conspicuity. Mean ASL cerebral blood flow and DSC perfusion values were obtained in main vascular territories. Kendall coefficient of concordance was calculated to evaluate the reliability of ratings. Spearman correlation coefficients were calculated to compare ratings and quantitative perfusion values between ASL and DSC perfusion maps. Results— ASL cerebral blood flow and DSC perfusion maps provided largely consistent results in delineating hypoperfused brain regions in AIS. Hyperemic lesions, which also appeared frequently in the AIS cases studied, were more conspicuous on ASL cerebral blood flow than on DSC cerebral blood flow, mean transit time and time to the maximum of the tissue residual function maps. Conclusions— As a rapid, noninvasive, and quantitative technique, ASL has clinical use in detecting blood flow abnormalities in patients with AIS. |
| Databáze: | OpenAIRE |
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