Irreversible Cerebellar Atrophy as a Complication of Short-Term Phenytoin Exposure: Clinical Improvement Following Discontinuation of the Culprit
| Autor: | Abdulrahman J. Alqahtani, Bader Shirah, Adnan Q Al-Malki, Hussein Algahtani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Phenytoin
Cerebellum Pediatrics medicine.medical_specialty Saudi Arabia Case Report 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Atrophy medicine Cerebellar Degeneration 0501 psychology and cognitive sciences Adverse effect Cerebellar ataxia business.industry 05 social sciences medicine.disease Discontinuation nervous system diseases medicine.anatomical_structure Neuronal plasticity Cerebellar atrophy medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Epilepsy Research |
| ISSN: | 2233-6257 2233-6249 |
| Popis: | Phenytoin (diphenylhydantoin) is a widely used antiepileptic drug for controlling both generalized and partial seizures. Reversible cerebellar symptoms, including cerebellar ataxia, have been recognized as an adverse event of phenytoin use for many years. On the other hand, cerebellar degeneration has been reported with chronic use in an epileptic patient treated with this drug. We are reporting an interesting case of phenytoin induced acute pan-cerebellar syndrome with cerebellar atrophy on neuro-imaging that improved many years after discontinuation of the drug. Discontinuation of phenytoin may give a chance for the patient to recover slowly, months after stopping the drug. It is very important for the attending neurologist to educate the patients and their families on some common clinical manifestations suggestive of drug toxicity and perform a regular follow-up and clinical examination at regular intervals. |
| Databáze: | OpenAIRE |
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