Variation in the proregion structure of heparin-binding EGF-like growth factor precursors
| Autor: | Tanya Loukianova, Evgenij Loukianov, Antoni G Wiedlocha, Sjur Olsnes |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Heparin-binding EGF-like growth factor medicine.medical_treatment Molecular Sequence Data Biology Polymerase Chain Reaction Cell Line Complementary DNA Chlorocebus aethiops Genetics medicine Animals Humans Amino Acid Sequence RNA Messenger Proline Cloning Molecular Protein Precursors Vero Cells Base Sequence Epidermal Growth Factor Growth factor Genetic Variation General Medicine Molecular biology Amino Acid Substitution Biochemistry COS Cells Intercellular Signaling Peptides and Proteins Leucine hormones hormone substitutes and hormone antagonists HeLa Cells Heparin-binding EGF-like Growth Factor |
| Zdroj: | Gene. 212:1-4 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(98)00139-5 |
| Popis: | In a previous study, we have isolated and characterized cDNA encoding a novel `short form' of heparin-binding EGF-like growth factor (SF HB-EGF) ( Loukianov et al., 1997 ). In the present work, we have found that cDNA for SF HB-EGF and for full-length HB-EGF are each represented by two variants, which we refer to as L and P forms. The L form is the previously known form of HB-EGF cDNA and encodes a leucine in position 33. The P form described in this report, encodes a proline in codon 33. The L33P substitution is predicted to cause a significant alteration in the proregion structure of SF HB-EGF and HB-EGF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect