Amyloid Metabolism and Amyloid-Targeting Blood-Based Biomarkers of Alzheimer’s Disease
| Autor: | Jung-Min Pyun, Nayoung Ryoo, Jeewon Suh, Young Chul Youn, SangYun Kim, Min Ju Kang, Young Ho Park |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Amyloid Central nervous system Disease 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Animals Humans Medicine Amyloid beta-Peptides business.industry Blood based biomarkers General Neuroscience Brain General Medicine Metabolism Psychiatry and Mental health Clinical Psychology 030104 developmental biology medicine.anatomical_structure Biomarker (medicine) Geriatrics and Gerontology business Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 75:685-696 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-200104 |
| Popis: | Amyloid-β (Aβ) is a key protein in Alzheimer's disease (AD) in that its accumulation induces complex pathological changes. Although there has been extensive research on the metabolism of Aβ in AD, new compelling results have recently emerged. Historically, the production and clearance of Aβ have been thought to originate in the central nervous system (CNS). However, recent evidence suggests that the production and clearance of Aβ can also occur in the peripheral system, and that the peripherally driven Aβ migrates to the CNS and induces amyloidopathy with subsequent AD pathologic changes in the brain. This concept implies that AD is not restricted to the CNS but is a systemic disease instead. As such, the development of blood-based biomarkers targeting Aβ is of great interest. Central and peripheral Aβ are both active contributors to the pathology of AD and interact bidirectionally. Measuring peripheral Aβ is not just observing the reflection of the residual Aβ removed from the CNS but also tracking the ongoing process of AD pathology. Additionally, blood-based biomarkers could be a more accessible tool in clinical and research settings. Through arduous research, several blood-based biomarker assays have demonstrated notable results. In this review, we describe the metabolism of Aβ and the amyloid-targeting blood-based biomarkers of AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|