Synthesis and anthelmintic activity of thioamide analogues of cyclic octadepsipeptides such as PF1022A
| Autor: | Gerhard Thielking, Wolfgang Gau, Peter Jeschke, Winfried Etzel, Gerhard Bonse, Katsuharu Iinuma, Achim Harder |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Hymenolepis nana Magnetic Resonance Spectroscopy Trichinella spiralis Mice Inbred Strains Peptides Cyclic Mice Structure-Activity Relationship Depsipeptides Helminths parasitic diseases medicine Animals Structure–activity relationship Anthelmintic Anthelmintics Depsipeptide Cyclic compound Sheep Molecular Structure biology Ecology Biological activity General Medicine biology.organism_classification Thioamides Biochemistry Insect Science Helminthiasis Animal Agronomy and Crop Science Haemonchus contortus medicine.drug |
| Zdroj: | Pest Management Science. 57:1000-1006 |
| ISSN: | 1526-4998 1526-498X |
| Popis: | The tetra- and mono-thionated cyclic octadepsipeptides represent novel cyclic octadepsipeptide derivatives with broad-spectrum activity against parasitic nematodes in mice and sheep. Some of these show better activity than the potent natural anthelmintic cyclic octadepsipeptide PF1022A against Hymenolepis nana, Heterakis spumosa and Trichinella spiralis larvae in mice. In particular, they show improved efficacy against Haemonchus contortus and Trichostrongylus colubriformis in sheep compared with PF1022A. Here we report on two different and simple synthetic pathways for this new class of thionated cyclic octadepsipeptides. |
| Databáze: | OpenAIRE |
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