Immunological profile changes following perioperative autologous vs. homologous blood transfusion in oncologic patients
| Autor: | Jan Oland, Suzana Kaufman, Yeheskel Levy, Rivka Yona, Shoshana Peller, Ruben Orda, Joel Sayfan |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cellular immunity medicine.medical_specialty Blood transfusion medicine.medical_treatment Breast Neoplasms Preoperative care Gastroenterology Blood Transfusion Autologous Immune system Breast cancer Internal medicine Preoperative Care Homologous chromosome medicine Humans Blood Transfusion Aged Aged 80 and over Postoperative Care Immunity Cellular business.industry General Medicine Perioperative Middle Aged medicine.disease Oncology Immunology Female Surgery Colorectal Neoplasms Erythrocyte Transfusion business Autotransfusion |
| Zdroj: | Journal of Surgical Oncology. 56:98-101 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | To determine the effect of perioperative blood transfusion on immunological parameters, T cells, T-cell subsets, and concanavalin A-induced suppression were measured in 25 patients with colorectal and breast cancer. During the operation, 15 patients received autologous blood and 10 patients had homologous transfusion. The immunological status was again determined after curative surgery. Before surgery, normal percentage of T lymphocytes, decreased ratios of helper/suppressor cells, and impaired con A-induced suppression were found. Following the operation, the helper and suppressor cell percentages reversed to normal, whereas the con A-induced suppression remained impaired. This change was significantly more pronounced in patients who received autologous blood transfusion than in the other group. Autotransfusion has an impact on immune parameters that might prove less detrimental to the clinical outcome in oncologic surgery than homologous transfusion. |
| Databáze: | OpenAIRE |
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