Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus
| Autor: | Phil A. Hart, Gaurav Aggarwal, Ananda Basu, Pratima Kamada, Suresh T. Chari, Sunil Srinivasan, Kari G. Rabe |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors endocrine system diseases Endocrinology Diabetes and Metabolism education Body weight Gastroenterology Article Endocrinology Weight loss Internal medicine Diabetes mellitus Pancreatic cancer Weight Loss Internal Medicine medicine Diabetes Mellitus Humans Hypoglycemic Agents DM - Diabetes mellitus Aged Hepatology business.industry Case-control study Cancer Middle Aged medicine.disease humanities Pancreatic Neoplasms Diabetes Mellitus Type 2 Case-Control Studies Female medicine.symptom business BMI - Body mass index |
| Zdroj: | Pancreas. 40(5) |
| ISSN: | 1536-4828 |
| Popis: | New-onset diabetes mellitus (DM) may herald pancreatic cancer (PaC). We determined whether changes in body weight distinguished PaC-associated DM (PaCDM) from type 2 DM.Among Olmsted County residents, we identified 29 PaCDM and 43 type 2 DM subjects who had serial fasting blood glucose measurements, new-onset DM, and no cancer-specific symptoms at DM onset. We compared body weight (kg) and fasting blood glucose (mg/dL) at DM onset, 1 to 2 years before and at index date in the 2 groups.Fasting blood glucose values were similar before and at the onset of DM. Before onset of DM, PaCDM and type 2 DM subjects had similar body weight (P = 0.80). However, at onset of DM, 59% of PaCDM subjects lost weight versus 30% of type 2 DM subjects (P = 0.02). At onset of DM, 56% of type 2 DM subjects gained weight versus 31% of PaCDM subjects (P = 0.04). By index date, PaCDM subjects lost more weight than type 2 DM subjects did (8.3 ± 8.3 vs 0.8 ± 4.8 kg, P0.01).Although new-onset primary type 2 DM is typically associated with weight gain, weight loss frequently precedes onset of PaCDM. The paradoxical development of diabetes in the face of ongoing weight loss may be an important clue to understanding the pathogenesis of PaCDM. |
| Databáze: | OpenAIRE |
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