Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook
| Autor: | Eduarda M. Santos, Mark R. Viant, Peter G. Lord, Caren C. Helbing, Daniel W. Bearden, Anne O’Neill, Charles R. Tyler, Rachel C. Skirrow, Yoshi Kagami, Heather L. Osachoff, Paul F. Hoekstra, Tim Collette, Li Liu, William H. Benson, William S. Baldwin, Lorraine Yu, Terry McIntyre, Francesco Falciani, Graham van Aggelen, Michael R. Embry, Stephen G. George, David C. Volz, Taisen Iguchi, Tim D. Williams, Gerald T. Ankley, Nancy D. Denslow, J. Kevin Chipman, Peter Kille, Ed J. Perkins, Don Versteeg, John A. Craft, Ioanna Katsiadaki, Jason Snape |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
regulatory toxicology
Health Toxicology and Mutagenesis Ecology (disciplines) 010501 environmental sciences 01 natural sciences 03 medical and health sciences transcriptomics Environmental monitoring Ecological risk 14. Life underwater Environmental degradation Environmental planning 030304 developmental biology 0105 earth and related environmental sciences environmental monitoring fish 0303 health sciences Government business.industry Environmental resource management Public Health Environmental and Occupational Health metabolomics 13. Climate action Commentary Environmental science Fish Toxicogenomics business Risk assessment environment microarray |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | Background: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics—Moving into Regulation and Monitoring, held 21–23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada). Objectives: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets. Discussion: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data. Conclusions: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach. |
| Databáze: | OpenAIRE |
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