BATO complexes derived from dimethoxy dioximes: Synthesis, characterization and biodistribution
| Autor: | David P. Nowotnik, K. Ramalingam, Adrian D. Nunn, Silvia S. Jurisson, Di Rocco Richard J, Rama K. Narra, Bruce L. Kuczynski |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Methylboronic acid Cancer Research Biodistribution Stereochemistry Chemistry Diastereomer Stereoisomerism Organotechnetium Compounds Medicinal chemistry High-performance liquid chromatography Rats Isotope Labeling Oximes Animals Molecular Medicine Gamma Cameras Spectrophotometry Ultraviolet Tissue Distribution Radiology Nuclear Medicine and imaging Tolylboronic acid Enantiomer Chromatography High Pressure Liquid Clearance |
| Zdroj: | Nuclear Medicine and Biology. 22:625-634 |
| ISSN: | 0969-8051 |
| Popis: | To prepare less lipophilic BATO complexes, two new methoxy-substituted dioximes were synthesized: cis-4,5-dimethoxycyclohexane-1,2-dione dioxime (DMCDO) and 1,4-dimethoxybutane-2,3-dione dioxime (DMDMG). 99mTcCl(DMCDO)3BMe (BMe = methylboronic acid) was prepared and characterized. Reversed-phase HPLC analyses of 99mTcCl(DMCDO)3BMe and 99mTcCl(DMCDO)3-p-TBA (p-TBA = p - tolylboronic acid) indicated that both of these complexes were mixtures of four enantiomeric pairs of diastereomers. Attempted preparation of a BATO complex from DMDMG gave a mixture of products. In rats, 99mTcCl(DMCDO)3BMe displayed more rapid liver and renal clearance than 99mTcCl(CDO)3BMe, but 99mTcCl(DMCDO)3BMe and 99mTcCl(DMCDO)3-p-TBA displayed low uptake in both heart and brain. |
| Databáze: | OpenAIRE |
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