Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations
| Autor: | Diane E. Gunson, Donald N. Mcmartin, Helen Han Hsu, Pritam S. Sahota, Robert H. Spaet |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Keratoacanthoma Pathology medicine.medical_specialty Adenoma 040301 veterinary sciences Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine 0403 veterinary science Lesion Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Pituitary adenoma Reference Values medicine Neoplasm Animals Molecular Biology business.industry Thyroid 04 agricultural and veterinary sciences Cell Biology Neoplasms Experimental medicine.disease Fibroadenoma Pancreatic islet cell adenoma Rats medicine.anatomical_structure Carcinogens Female medicine.symptom business |
| Zdroj: | Toxicologic pathology. 20(2) |
| ISSN: | 0192-6233 |
| Popis: | Historical data are presented for neoplasms and related proliferative lesions from 1,170 Sprague-Dawley rats that served as controls in 9 carcinogenicity (2 year) studies conducted in the Safety Evaluation Facility of Ciba-Geigy Corporation, Summit, New Jersey. The most common neoplasm was pituitary adenoma, which occurred in 62.2% of the male and 84.7% of the female rats. Incidences of other neoplasms that occurred in more than 6.0% of the rats were, for males, benign pheochromocytoma (19.0%), cutaneous keratoacanthoma (7.9%), pancreatic islet cell adenoma (7.5%), benign testicular interstitial cell tumor (6.5%), and thyroid C-cell adenoma (6.5%). For females these incidences were mammary fibroadenoma (31.3%), mammary adenocarcinoma (16.8%), and mammary adenoma (6.5%). Focal cortical hypertrophy/cystic degeneration of the adrenal, a focal nonneoplastic lesion of zona fasiculata cells that often degenerate into large cysts, was present in 23.4% of all male and 82.7% of all female rats. Criteria for the differential diagnoses of selected neoplasms and related lesions are presented. |
| Databáze: | OpenAIRE |
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