Incidental computer tomography radiologic findings through research participation in the North Texas Healthy Heart Study
| Autor: | Elizabeth Balyakina, Roberto Cardarelli, Kimberly G. Fulda, Anna Espinoza, Kendra Malone |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Population Coronary Artery Disease Best interests Asymptomatic Article Coronary artery disease Intervention (counseling) medicine Humans Medical physics education Vascular Calcification Retrospective Studies education.field_of_study Incidental Findings business.industry Medical findings Public Health Environmental and Occupational Health Retrospective cohort study Middle Aged medicine.disease Texas medicine.anatomical_structure Human Experimentation Physical therapy Abdomen Female medicine.symptom Family Practice business Tomography X-Ray Computed |
| Zdroj: | Journal of the American Board of Family Medicine : JABFM. 27(3) |
| ISSN: | 1558-7118 |
| Popis: | Background: Although variation exists in the classification and practice of managing clinical findings in research, emerging views suggest that researchers bear some responsibility in the management of incidental findings. This study contributes to the documentation of the population characteristics and prevalence of medical findings incidental to research participation, specifically findings related to coronary calcium scores and computed tomography (CT) scans that investigated cardiovascular disparities in an asymptomatic population. Methods: A total of 571 asymptomatic adult participants were recruited in the North Texas Healthy Heart Study. Participants completed a 16-slice CT scan of the heart and abdomen. Findings of radiology reports and 3 years of follow-up documentation were reviewed. Results: A total of 246 clinically apparent findings were identified in 169 asymptomatic participants (32.9% of participants who completed a CT scan). Another 245 participants (48%) had findings of unknown significance, a total of 307 findings. At least 4 cases in this study led to a clinically significant intervention. Conclusion: Although CT scans were completed for research purposes, study procedures resulted in the diagnosis and treatment of individuals who were previously asymptomatic. Potential clinical benefits in imaging research are moderated by considerations regarding possible harm and costs resulting from uncertain findings and the use of CT scans for nonclinical purposes. The continued development of protocols for the handling of incidental findings in research and the establishment of guidelines are needed to ensure that research procedures mirror the best interests of participants. |
| Databáze: | OpenAIRE |
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