Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
| Autor: | Soichiro Funaki, Keisuke Kawasaki, Yasushi Shintani, Ayumi Shibata, Tomomi Isono, Naoko Ose |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Thymoma Case Report autoimmune disease Case Reports multiple sclerosis Diseases of the respiratory system thymus medicine Demyelinating disease video‐assisted thoracoscopic thymectomy biology RC705-779 business.industry Multiple sclerosis Mediastinum Germinal center thymoma medicine.disease Myelin basic protein medicine.anatomical_structure Methylprednisolone biology.protein Immunohistochemistry business medicine.drug |
| Zdroj: | Respirology Case Reports, Vol 9, Iss 9, Pp n/a-n/a (2021) Respirology Case Reports |
| ISSN: | 2051-3380 |
| Popis: | The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown and surgical resection has not been optimized. A 39‐year‐old woman was administrated methylprednisolone for newly diagnosed multiple sclerosis. A thymic tumour was found in the antero‐superior mediastinum via computed tomography of the chest. Video‐assisted thoracoscopic thymectomy was performed. Histologically, the tumour was diagnosed as Type AB thymoma. Immunohistochemical staining showed positive myelin basic protein (MBP) in the cytosol of spindle cells in the tumour specimen. Germinal centres or lymphocytes infiltration were not noted. Ectopic MBP presentation in thymoma might be correlated with DD. The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown and surgical resection has not been optimized. We present the case of a 39‐year‐old woman with newly diagnosed multiple sclerosis with a thymic tumour in the antero‐superior mediastinum. Video‐assisted thoracoscopic thymectomy was performed and the tumour was diagnosed as a Type AB thymoma. Immunohistochemical staining showed positive myelin basic protein (MBP) in the cytosol of spindle cells in the tumour specimen. This case suggests that ectopic MBP presentation in thymoma might be correlated with DD. |
| Databáze: | OpenAIRE |
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