Trends in transmitted drug-resistant HIV-1 and demographic characteristics of newly diagnosed patients: Nationwide surveillance from 2003 to 2008 in Japan

Autor: Rumi Minami, Ichiro Koga, Shigeru Yoshida, Junko Hattori, Teiichiro Shiino, Hiroyuki Gatanaga, Yasuo Ota, Mami Nagashima, Ito Toshihiro, Haruyo Mori, Yoko Kojima, Masayasu Oie, Makiko Kondo, Dai Watanabe, Shingo Kato, Tsunefusa Hayashida, Shinichi Oka, Takuma Shirasaka, Masahiro Yamamoto, Atsuhisa Ueda, Satoru Sasaki, Mikio Ueda, Masakazu Matsuda, Shiro Ibe, Masao Tateyama, Yoshinari Tanabe, Jiro Fujita, Wataru Sugiura, Noboru Takata, Kenji Sadamasu, Yoshiaki Ishigatsubo, Takao Koike, Yoshiyuki Yokomaku
Rok vydání: 2010
Předmět:
Zdroj: Antiviral Research. 88:72-79
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2010.07.008
Popis: The emergence and transmission of drug-resistant human immunodeficiency virus-1 (HIV-1) compromises antiretroviral treatment for HIV-1. Thus, testing for drug resistance is recommended at diagnosis and before initiating highly active antiretroviral treatment. We conducted an epidemiological study enrolling newly diagnosed patients between 2003 and 2008 in our nationwide surveillance network. In the 6-year study period, the prevalence of drug-resistant HIV-1 among 2573 patients, consisting mainly of Japanese men in their late-30s and infected through male-to-male sexual contacts, followed an increasing trend from 5.9% (16/273) in 2003 to 8.3% (50/605) in 2008. Nucleoside reverse transcriptase inhibitor-associated mutations predominated in each year, with T215 revertants being the most abundant. The predictive factor for drug-resistant HIV-1 transmission was subtype B (OR=2.36; p=0.004), and those for recent HIV-1 infection were male gender (OR=3.79; p=0.009), MSM behavior (OR=1.67; p=0.01), Japanese nationality (OR=2.31; p=0.008), and subtype B (OR=5.64; p
Databáze: OpenAIRE