Improved quality of life, immunoglobulin G levels, and infection rates in patients with primary immunodeficiency diseases during self-treatment with subcutaneous immunoglobulin G
| Autor: | Melvin Berger, Elyse Murphy, Patty Riley, Garrett E. Bergman |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Health Status Immunoglobulins Self Administration Infections Infusions Subcutaneous Immunoglobulin G Quality of life Medicine Humans Immunologic Factors In patient Child Aged biology business.industry Genetic heterogeneity Immunologic Deficiency Syndromes General Medicine Middle Aged medicine.disease Clinical trial Mental Health Child Preschool Immunology biology.protein Primary immunodeficiency Quality of Life Female Drug Eruptions Antibody Sick Leave Self-administration business |
| Zdroj: | Southern medical journal. 103(9) |
| ISSN: | 1541-8243 |
| Popis: | Primary immunodeficiency diseases (PIDDs) include a large class of genetically heterogeneous disorders which predispose patients to significant risk of serious and chronic/recurrent infections, as well as reduced quality of life (QoL). Intravenous immunoglobulin (IVIG) therapy improves the well being of PIDD patients; however, the need for venous access and potentially severe side effects frequently require administration in medical facilities. We evaluated the long-term (12-month) experience with home-based self infusions of subcutaneous immune globulin (SCIG) in patients with PIDD on health-related QoL, rates of serious bacterial infections, and all other infections.Adults (n = 42) and children (n = 9) with PIDD, previously treated with clinic-based IVIG, were trained to self administer SCIG at home. QoL (SF-36(R) and CHQ-PF50 questionnaires), serious bacterial infections, serum immunoglobulin G (IgG) levels, overall infections, and incidence of adverse events were recorded at predetermined intervals.All patients had improved perceptions of general health (adults P = 0.047, children P = 0.037). Adults also had marked improvement in the bodily pain and vitality assessments, and parents had improved perceptions of personal and family activities. Serum IgG levels were maintained at mean levels 25% higher than previous troughs on IVIG. There were 162 infections overall for an annual rate of 3.42/patient, but only 1 serious bacterial infection was observed (0.03/patient/yr). An average of 4.5 days/yr was missed from work or school per patient.Home SCIG therapy was safe and led to improved perceptions of general health, higher serum IgG levels, and very low rates of infections and days missed from work/school. |
| Databáze: | OpenAIRE |
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