Comparison of Whole Salivary Lactate Dehydrogenase Level in Patients With and Without Periodontal Disease
| Autor: | Maral Saremi, Neda Rastegarfard, Samare Kafilzade, Sara Soheilifar, Mohsen Bidgoli, Janet Moradi Haghgoo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Periodontitis medicine.medical_specialty Saliva business.industry Dentistry 030206 dentistry medicine.disease Gastroenterology Kowsar lcsh:RK1-715 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Periodontal disease Statistical significance Lactate dehydrogenase Internal medicine lcsh:Dentistry medicine Lactate dehydrogenase level In patient business |
| Zdroj: | Dental journal of Hamadan University of Medical Sciences, Vol 8, Iss 4 (2016) |
| ISSN: | 2423-7582 |
| Popis: | Background Tracking various biomarkers in serum, gingival crevicular fluid (GCF), and saliva has been introduced as a diagnostic tool for periodontal disease detection. Objectives The aim of this study was to compare salivary lactate dehydrogenase (LDH) levels in subjects with periodontal disease and levels in subjects without periodontal disease. Materials and Methods In this case-control study, 170 patients at Hamadan faculty of Dentistry, including patients with periodontal disease and patients with normal periodontium, were selected and divided into test and control groups. Unstimulated saliva was collected in the same situation from the test and control groups. Each saliva sample was analyzed to measure salivary LDH level on the day of collection, by using commercially available kits according to the manufacturers’ instructions. A statistical T-test was employed to evaluate significant differences among groups. Results The mean LDH levels in the test and control groups were 1071.67 ± 731.004 and 550.91 ± 217.215, respectively. As the level of statistical significance was set at P < 0.05, data analysis showed a significant difference between the LDH enzymatic level in the test and control groups (P = 0.000). Comparison of the LDH enzymatic level in subjects with different genders in the test and control groups showed no significant differences (P = 0.340). Conclusions Salivary LDH levels can be used as marker of periodontal disease for screening periodontitis in large populations. |
| Databáze: | OpenAIRE |
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