Induction of allergic encephalomyelitis using hydrosoluble adjuvant and the tryptophan region of myelin basic protein
| Autor: | D. Migliore-Samour, Millie Thompson, Pierre Jollfès, Fred C. Westall |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Peptide Biosynthesis
Encephalomyelitis Autoimmune Experimental Injections Intradermal medicine.medical_treatment Encephalomyelitis Immunology Guinea Pigs Peptide Biology Mycobacterium tuberculosis Antigen Adjuvants Immunologic medicine Animals chemistry.chemical_classification Tryptophan Brain Myelin Basic Protein Allergic Encephalomyelitis medicine.disease biology.organism_classification Myelin basic protein chemistry Spinal Cord biology.protein Female Peptides Adjuvant |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0090-0877 |
| Popis: | Experimental allergic encephalomyelitis has been induced in guinea pigs using the encephalitogenic tryptophan peptide as antigen and a hydrosoluble adjuvant extracted from Mycobacterium tuberculosis, var. hominis, strain H37Ra. The maximum response was observed using 100mug of adjuvant per animal. This is a quantity of adjuvant substantially higher than was necessary to induce disease utilizing the whole myelin basic protein as antigen. |
| Databáze: | OpenAIRE |
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