A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Autor: A. Radu Aricescu, Yuki Morioka, Yuka Takeuchi, Tatsuya Shimada, Oleg Senkov, Rahul Kaushik, Kosei Takeuchi, Michisuke Yuzaki, Hiroyuki Sasakura, Stoyan Stoyanov, Alexander Dityatev, Maura Ferrer-Ferrer, Kunimichi Suzuki, Masashi Ikeno, Eriko Miura, Amber J. Clayton, Keiko Matsuda, Wataru Kakegawa, Veronica T. Chang, Masahiko Watanabe, Jonathan Elegheert, Inseon Song, Shintaro Otsuka
Přispěvatelé: Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Nervous system
chemistry [Recombinant Proteins]
drug effects [Synapses]
Hippocampus
therapy [Cerebellar Ataxia]
Mice
0302 clinical medicine
Postsynaptic potential
drug effects [Spine]
ComputingMilieux_MISCELLANEOUS
Multidisciplinary
Glutamate receptor
therapeutic use [Protein Precursors]
genetics [Receptors
Glutamate]
therapeutic use [Nerve Tissue Proteins]
Motor coordination
chemistry [Protein Precursors]
medicine.anatomical_structure
Excitatory postsynaptic potential
pharmacology [Recombinant Proteins]
Ionotropic effect
pharmacology [C-Reactive Protein]
Biology
Neurotransmission
03 medical and health sciences
Glutamatergic
Protein Domains
medicine
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
therapeutic use [Recombinant Proteins]
therapy [Alzheimer Disease]
drug effects [Neural Pathways]
therapeutic use [C-Reactive Protein]
metabolism [Receptors
AMPA]
Mice
Mutant Strains
Mice
Inbred C57BL
pharmacology [Protein Precursors]
Disease Models
Animal
030104 developmental biology
HEK293 Cells
ddc:320
pharmacology [Nerve Tissue Proteins]
chemistry [Nerve Tissue Proteins]
Neuroscience
030217 neurology & neurosurgery
chemistry [C-Reactive Protein]
physiology [Spine]
Zdroj: Science
Science, American Association for the Advancement of Science, 2020, 369 (6507), ⟨10.1126/science.abb4853⟩
Science / Science now 369(6507), eabb4853-(2020). doi:10.1126/science.abb4853
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.abb4853⟩
Popis: Synthetic excitatory synaptic organizer The human brain contains trillions of synapses within a vast network of neurons. Synapse remodeling is essential to ensure the efficient reception and integration of external stimuli and to store and retrieve information. Building and remodeling of synapses occurs throughout life under the control of synaptic organizer proteins. Errors in this process can lead to neuropsychiatric or neurological disorders. Suzuki et al. combined structural elements of natural synaptic organizers to develop an artificial version called CPTX, which has different binding properties (see the Perspective by Salinas). CPTX could act as a molecular bridge to reconnect neurons and restore excitatory synaptic function in animal models of cerebellar ataxia, familial Alzheimer's disease, and spinal cord injury. The findings illustrate how structure-guided approaches can help to repair neuronal circuits. Science , this issue p. eabb4853 ; see also p. 1052
Databáze: OpenAIRE
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