| Autor: |
Shen, Zhang, Bin-Yan, Zhong, Lei, Zhang, Wan-Sheng, Wang, Cai-Fang, Ni |
| Rok vydání: |
2022 |
| Zdroj: |
World Journal of Gastrointestinal Surgery. 14:528-537 |
| ISSN: |
1948-9366 |
| DOI: |
10.4240/wjgs.v14.i6.528 |
| Popis: |
Multi-session transarterial chemoembolization (TACE) is usually needed for the treatment of intermediate-stage hepatocellular carcinoma (HCC), but it may not always have a positive influence on prognosis due to high heterogeneity of HCC. To avoid ineffective repeated TACE, the concept of TACE failure/refractoriness has been proposed by several organizations and is being addressed using tyrosine kinase inhibitors. The concept of TACE failure/refractoriness is controversial due to ambiguous definitions and low evidence-based data. To date, only a few studies have examined the rationality concerning the definition of TACE failure/refractoriness, although the concept has been introduced and applied in many TACE-related clinical trials. This review focuses on some of the issues related to different versions of TACE failure/refractoriness, the rationality of related definitions, and the feasibility of continuing TACE after so-called failure/refractoriness based on published evidence. A suggestion to re-define TAEC failure/refractoriness is also put forward. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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