Potential targetability of multi-walled carbon nanotube loaded with silver nanoparticles photosynthesized from Ocimum tenuiflorum (tulsi extract) in fertility diagnosis
| Autor: | Rakhi Jha, Pradeep K. Jha, Suresh Vir Singh Rana, Sathishkumar Gnanasekar, Dilip Rout, Maidul Hossain |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Nanotube Silver Metal Nanoparticles Pharmaceutical Science Nanotechnology 02 engineering and technology Carbon nanotube Microscopy Atomic Force 010402 general chemistry 01 natural sciences Silver nanoparticle law.invention law Humans Photosynthesis Fourier transform infrared spectroscopy Intracellular part Calorimetry Differential Scanning biology Nanotubes Carbon Chemistry 021001 nanoscience & nanotechnology Ocimum biology.organism_classification 0104 chemical sciences Fertility Chemical engineering Ocimum sanctum Female Nanocarriers 0210 nano-technology Biosensor |
| Zdroj: | Journal of Drug Targeting. 25:616-625 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.1080/1061186x.2017.1306534 |
| Popis: | Nanocarrier mediated targeted delivery and biosensing in reproductive health care is a major exploratory domain. This work demonstrates the loading of silver nanoparticle (AgNP) inside the multiwalled carbon nanotube (MWCNT) and their targetability to the intracellular part of the sperm cell for its further application in biosensing based infertility diagnosis. Ocimum tenuiflorum (tulsi extract) mediated photosynthesized AgNP exhibited spherical shape, 5–40 nm size and surface plasmonic resonance at 430 nm. After loading of freshly prepared AgNP into emulsified MWCNT, the loading was confirmed with spectroscopic and microscopic methods. FTIR analysis displayed significant shifting at 3450 cm−1 (–OH stretching) and 1615 cm−1 (CNT back bone) which validated the binding of AgNP with MWCNT and interestingly heat flow analysis revealed that Ag loaded MWCNT has greater stability than AgNP. Moreover, AFM based surface profile height analysis clearly showed the loading of AgNP inside MWCNT as surface heig... |
| Databáze: | OpenAIRE |
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