Pre-operative and post-operative cognitive deficits in patients with supratentorial meningiomas
| Autor: | Kalyan Bommakanti, Alladi Suvarna, Shanmukhi Somayajula, Santoshi Kumari Chadalawadi, Shailaja Mekala, Aniruddh Kumar Purohit, Padmaja Gaddamanugu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Neuropsychological Tests Preoperative care Meningioma Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Preoperative Care Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Meningeal Neoplasm Prospective Studies Young adult Prospective cohort study Postoperative Care Supratentorial Meningioma business.industry Supratentorial Neoplasm Supratentorial Neoplasms Cognition General Medicine Middle Aged medicine.disease nervous system diseases Surgery 030220 oncology & carcinogenesis Female Neurology (clinical) Radiology Cognition Disorders business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurology and Neurosurgery. 143:150-158 |
| ISSN: | 0303-8467 |
| DOI: | 10.1016/j.clineuro.2016.02.033 |
| Popis: | Objectives Cognitive deficits caused by extra-axial benign brain tumors like meningiomas and the course of these deficits after surgery is not well known. The aim of the study is to assess the pre-operative and post-operative cognitive functions in patients with meningiomas in the supratentorial compartment. Materials and methods In this prospective study, patients with clinico-radiological diagnosis of supratentorial meningioma, operated upon and later confirmed by histopathological examination, were included. The patients were evaluated for cognitive deficits before and after surgery. The various clinical and radiological factors influencing the cognitive status were evaluated. Results A total of 57 patients were enrolled into the study. Out of 57, 22 were males and 35 were females. The frontal group had 22 patients, the parietal group had 10 patients, the temporal group had 10 patients, the occipital group had 6 patients, and the suprasellar group had 9 patients. Meningiomas, although extra-axial, caused significant cognitive deficits in 42 patients (73.7%). The highest frequency of cognitive deficits is seen in the frontal and temporal group of meningiomas (90% each). Frontal meningiomas with volume greater than 35cc and peritumoral edema greater than 40cc caused a higher frequency of cognitive deficits. Also, patients with raised ICP had significant cognitive deficits. Postoperatively there was a significant improvement in the cognitive functions in the frontal and temporal groups. Conclusion Meningiomas cause cognitive deficits in 73.7% of patients. Anatomical location of meningioma, elevated ICP, the volume of meningioma and extent of peritumoral edema significantly influence the incidence of cognitive deficits. Post-operatively, the cognitive deficits improve significantly in the frontal and temporal group. |
| Databáze: | OpenAIRE |
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