Why don’t serum vitamin D concentrations associate with BMD by DXA? A case of being ‘bound’ to the wrong assay? Implications for vitamin D screening
| Autor: | Graeme L. Close, Bruce A. Hamilton, Anissa Cherif, Mathew G Wilson, Richard J. Allison, Abdulaziz Farooq |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Adolescent Bone density Vitamin D-binding protein Population Biological Availability 030209 endocrinology & metabolism Physical Therapy Sports Therapy and Rehabilitation RC1200 Young Adult 03 medical and health sciences chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Bone Density Internal medicine medicine Vitamin D and neurology Humans Free hormone Orthopedics and Sports Medicine Vitamin D education Bone mineral Serum vitamin education.field_of_study business.industry Vitamin D-Binding Protein 030229 sport sciences General Medicine Endocrinology chemistry Athletes Parathyroid Hormone business Biomarkers |
| Zdroj: | British Journal of Sports Medicine. 52:522-526 |
| ISSN: | 1473-0480 0306-3674 |
| DOI: | 10.1136/bjsports-2016-097130 |
| Popis: | BackgroundThe association between bone mineral density (BMD) and serum25-hydroxyvitamin D (25(OH)D) concentration is weak, particularly in certain races (eg, BlackAfrican vs Caucasian) and in athletic populations. We aimed to examine if bioavailable vitamin D rather than serum 25(OH)D was related to markers of bone health within a racially diverse athletic population.MethodsIn 604 male athletes (Arab (n=327), Asian (n=48), Black (n=108), Caucasian (n=53) and Hispanic (n=68)), we measured total 25(OH)D, vitamin D-binding protein and BMD by DXA. Bioavailable vitamin D was calculated using the free hormone hypothesis.ResultsFrom 604 athletes, 21.5% (n=130) demonstrated severe 25(OH)D deficiency, 37.1% (n=224) deficiency, 26% (n=157) insufficiency and 15.4% (n=93) sufficiency. Serum 25(OH)D concentrations were not associated with BMD at any site. After adjusting for age and race, bioavailable vitamin D was associated with BMD (spine, neck and hip). Mean serum vitamin D binding protein concentrations were not associated with 25(OH)D concentrations (p=0.392).ConclusionRegardless of age or race, bioavailable vitamin D and not serum 25(OH)D was associated with BMD in a racially diverse athletic population. If vitamin D screening is warranted, clinicians should use appropriate assays to calculate vitamin D binding protein and bioavailable vitamin D levels concentrations than serum 25(OH)D. In turn, prophylactic vitamin D supplementation to ‘correct’ insufficient athletes should not be based on serum 25(OH)D measures. |
| Databáze: | OpenAIRE |
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