Hippocampal spatial memory representations in mice are heterogeneously stable
| Autor: | William Mau, Michael E. Hasselmo, Samuel Levy, David W. Sullivan, Nathaniel R. Kinsky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Computer science
Cognitive Neuroscience Population Hippocampus Hippocampal formation Article 050105 experimental psychology Task (project management) Mice 03 medical and health sciences Neural activity 0302 clinical medicine Calcium imaging Single task medicine Animals 0501 psychology and cognitive sciences education Spatial Memory Neurons education.field_of_study 05 social sciences medicine.anatomical_structure Place Cells Space Perception Neuron Cues Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Hippocampus |
| ISSN: | 1098-1063 1050-9631 |
| DOI: | 10.1002/hipo.23272 |
| Popis: | The population of hippocampal neurons actively coding space continually changes across days as mice repeatedly perform tasks. Many hippocampal place cells become inactive while other previously silent neurons become active, challenging the idea that stable behaviors and memory representations are supported by stable patterns of neural activity. Active cell replacement may disambiguate unique episodes that contain overlapping memory cues, and could contribute to reorganization of memory representations. How active cell replacement affects the evolution of representations of different behaviors within a single task is unknown. We trained mice to perform a Delayed Non-Match to Place (DNMP) task over multiple weeks, and performed calcium imaging in area CA1 of the dorsal hippocampus using head-mounted miniature microscopes. Cells active on the central stem of the maze “split” their calcium activity according to the animal’s upcoming turn direction (left or right), the current task phase (study or test), or both task dimensions, even while spatial cues remained unchanged. We found that, among reliably active cells, different splitter neuron populations were replaced at unequal rates, resulting in an increasing number of cells modulated by turn direction and a decreasing number of cells with combined modulation by both turn direction and task phase. Despite continual reorganization, the ensemble code stably segregated these task dimensions. These results show that hippocampal memories can heterogeneously reorganize even while behavior is unchanging. |
| Databáze: | OpenAIRE |
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