Supplementation with the Prebiotic High-Esterified Pectin Improves Blood Pressure and Cardiovascular Risk Biomarker Profile, Counteracting Metabolic Malprogramming

Autor:	Francisco Garcia-Carrizo, Sebastià Galmés Monroig, Catalina Pico, Ana Maria Rodriguez Guerrero, Andreu Palou
Rok vydání:	2022
Předmět:	Blood Pressure General Chemistry Lipids Rats Prebiotics Pregnancy Cardiovascular Diseases Risk Factors Heart Disease Risk Factors Animals Pectins Female General Agricultural and Biological Sciences Atrial Natriuretic Factor Biomarkers
Zdroj:	Journal of Agricultural and Food Chemistry. 70:13200-13211
ISSN:	1520-5118 0021-8561
DOI:	10.1021/acs.jafc.2c03143
Popis:	Supplementation with the prebiotic pectin is associated with beneficial health effects. We aimed to characterize the cardioprotective actions of chronic high-esterified pectin (HEP) supplementation (10%) in a model of metabolic malprogramming in rats, prone to obesity and associated disorders: the progeny of mild calorie-restricted dams during the first half of pregnancy. Results show that pectin supplementation reverses metabolic malprogramming associated with gestational undernutrition. In this sense, HEP supplementation improved blood pressure, reduced heart lipid content, and regulated cardiac gene expression of atrial natriuretic peptide and lipid metabolism-related genes. Moreover, it caused an elevation in circulating levels of fibroblast growth factor 21 and a higher expression of its co-receptor β-klotho in the heart. Most effects are correlated with the gut levels of beneficial bacteria promoted by HEP. Therefore, chronic HEP supplementation shows cardioprotective actions, and hence, it is worth considering as a strategy to prevent programmed cardiometabolic alterations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5193dbb19f69bf6d91b2a5046a0ffbd https://doi.org/10.1021/acs.jafc.2c03143 Zobrazit plný text záznamu