Diagnosis of hyperglycemia in a cohort of Brazilian subjects
| Autor: | Cláudia H.M.C. Oliveira, Omar M. Hauache, André F. Reis, Carolina S. V. Oliveira, Gilberto Velho, Rui M. B. Maciel, Cláudia M. Ferrer, Cristina Khawali, Maria Teresa Ghiringhello, Teresinha T. Tachibana, José Gilberto H. Vieira |
|---|---|
| Přispěvatelé: | Fleury Inst, Universidade Federal de São Paulo (UNIFESP), INSERM U695 |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Advanced and Specialized Nursing
Glucose tolerance test medicine.medical_specialty endocrine system diseases medicine.diagnostic_test business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment nutritional and metabolic diseases medicine.disease Impaired fasting glucose carbohydrates (lipids) Impaired glucose tolerance Endocrinology Oral administration Internal medicine Diabetes mellitus Internal Medicine medicine business hormones hormone substitutes and hormone antagonists Pancreatic hormone Glycemic |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| Popis: | Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) represent intermediate states between normal fasting glucose (NFG) or normal glucose tolerance (NGT), respectively, and diabetes (1). The regulation of fasting and glucose concentrations after an oral glucose load is dependent on different physiological mechanisms (2), and current evidence suggests that IFG and IGT have different pathophysiologies (3,4). Measurement of fasting plasma glucose (FPG) is the most frequently used screening test for diabetes. However, the oral glucose tolerance test (OGTT) might be a preferable test because FPG underestimates the severity of glucose intolerance (5,6) and because IFG and IGT define two distinct populations with only partial overlap (5,7,8). The present study was undertaken to compare insulin sensitivity and insulin secretion profiles associated with different stages of hyperglycemia as assessed by FPG only or by FPG and 2-h plasma glucose during an OGTT. We analyzed data from 900 subjects without previously known diabetes who underwent an OGTT for diagnostic purposes at Fleury Institute, Sao Paulo, Brazil. A double-glycemic status was determined for each subject. A first set was based on FPG only as follows: NFG (FPG … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|