Chemo-Enzymatic Synthesis of Poly(4-piperidine lactone- b-ω-pentadecalactone) Block Copolymers as Biomaterials with Antibacterial Properties
| Autor: | Meidong Lang, Jinghao Pan, Andreas Heise, Yan Xiao, Dong Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Staphylococcus aureus
Polymers and Plastics Biocompatibility Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Ring-opening polymerization Biomaterials Hydrolysis chemistry.chemical_compound Lactones Mice Piperidines Materials Chemistry Copolymer Animals Cationic polymerization 3T3 Cells 021001 nanoscience & nanotechnology Combinatorial chemistry Copolyester 0104 chemical sciences Anti-Bacterial Agents chemistry Piperidine 0210 nano-technology Antibacterial activity |
| Zdroj: | Biomacromolecules. 19(7) |
| ISSN: | 1526-4602 |
| Popis: | With increasing troubles in bacterial contamination and antibiotic-resistance, new materials possessing both biocompatibility and antimicrobial efficacy are supposed to be developed for future biomedical application. Herein, we demonstrated a chemo-enzymatic ring opening polymerization (ROP) approach for block copolyester, that is, poly(4-benzyl formate piperidine lactone- b-ω-pentadecalactone) (PNPIL- b-PPDL), in a one-pot two-step process. Afterward, cationic poly(4-piperidine lactone- b-ω-pentadecalactone) (PPIL- b-PPDL) with pendent secondary amino groups was obtained via acidic hydrolysis of PNPIL- b-PPDL. The resulting cationic block copolyester exhibited high antibacterial activity against Gram negative E. coli and Gram positive S. aureus, while showed low toxicity toward NIH-3T3 cells. Moreover, the antibacterial property, cytotoxicity and degradation behavior could be tuned simply by variation of PPIL content. Therefore, we anticipate that such cationic block copolymers could potentially be applied as biomaterials for medicine or implants. |
| Databáze: | OpenAIRE |
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