Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China
| Autor: | Juan Tao, Liu Yang, Yingli Nie, Zexing Song, Xu Han |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Immunoglobulin A China medicine.medical_specialty IgA Vasculitis Gastrointestinal Diseases Logistic regression Biochemistry Serology Fibrin Fibrinogen Degradation Products Leukocyte Count Young Adult chemistry.chemical_compound High-density lipoprotein Internal medicine Genetics medicine Humans Receptors Immunologic Retrospective Studies Univariate analysis Kidney biology business.industry Retrospective cohort study Middle Aged medicine.disease Hospitalization medicine.anatomical_structure chemistry biology.protein Female Kidney Diseases Lipoproteins HDL Vasculitis business Biomarkers |
| Zdroj: | Current Medical Science. 41:888-893 |
| ISSN: | 2523-899X 2096-5230 |
| DOI: | 10.1007/s11596-021-2440-0 |
| Popis: | Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV. A retrospective analysis was performed for adult IgAV patients, who were hospitalized in Wuhan Union Hospital between January 2016 and December 2019. A total of 259 patients were enrolled, and the pre-treatment serological markers were comprehensively assessed. In the present study, 49.0% and 33.2% of patients developed renal and gastrointestinal (GI) involvement, respectively. Furthermore, the elevated levels of white blood cells count, D-Dimer (D-D), C-reactive protein (CRP) and neutrophil granulocyte ratio (NE%) >60% were significantly associated with GI involvement in the univariate analysis, while the decrease in high density lipoprotein level, and the elevated D-D and CRP levels were significantly associated with renal involvement (P |
| Databáze: | OpenAIRE |
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