The effect of EMD 57033, a novel cardiotonic agent, on the relaxation of skinned cardiac and skeletal muscle produced by photolysis of diazo-2, a caged calcium chelator
| Autor: | S. Lipscomb, S. J. Simnett, I. P. Mulligan, Christopher C. Ashley |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Cardiotonic Agents Physiology Muscle Relaxation Clinical Biochemistry Guinea Pigs Rana temporaria chemistry.chemical_element Calcium Phenoxyacetates Contractility chemistry.chemical_compound Physiology (medical) Internal medicine medicine Animals Chelating Agents Photolysis Thiadiazines Muscles Skeletal muscle Diazonium Compounds Myocardial Contraction Adenosine Diphosphate Endocrinology medicine.anatomical_structure chemistry Mechanism of action Biophysics Quinolines Flash photolysis Relaxation (physics) Diazo medicine.symptom Myofibril |
| Zdroj: | Pflugers Archiv : European journal of physiology. 425(1-2) |
| ISSN: | 0031-6768 |
| Popis: | EMD 57033 is thought to produce its potentiating effect by increasing the apparent calcium sensitivity of myofibrils. We have investigated the effect of 10 microM EMD 57033 on relaxation speed, induced by flash photolysis of 2mM diazo-2 (a caged Ca2+ chelator), in skinned semitendinosus frog muscle fibres and guinea-pig trabeculae. 10 microM EMD 57033 has no effect on the relaxation speed of semitendinosus fibres. In trabeculae, EMD 57033 slightly increases the relaxation speed slightly, in contrast to ADP which produces a slowing. 1mM ADP combined with 10 microM EMD 57033 slows relaxation but not to the degree seen with ADP alone. Like ADP, EMD 57033 increases the number of cross-bridges in the force producing state, but unlike ADP does not affect the transition rates involved in relaxation. |
| Databáze: | OpenAIRE |
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