Simulating uterine contraction by using an electro-chemo-mechanical model
| Autor: | Carl-Johan Thore, Jonas Stålhand, Babak Sharifimajd |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Contraction (grammar) 0206 medical engineering Finite Element Analysis Uterus Action Potentials 02 engineering and technology Myosins Uterine contractility Models Biological Uterine contraction 03 medical and health sciences Uterine Contraction Smooth muscle Pregnancy medicine Pressure Humans Computer Simulation Chemistry Chemo mechanical Mechanical Engineering Gap junction Myometrium Muscle Smooth Anatomy 020601 biomedical engineering Biomechanical Phenomena 030104 developmental biology medicine.anatomical_structure Modeling and Simulation Calcium Female medicine.symptom Biotechnology Biomedical engineering |
| Zdroj: | Biomechanics and modeling in mechanobiology. 15(3) |
| ISSN: | 1617-7940 |
| Popis: | Contractions of uterine smooth muscle cells consist of a chain of physiological processes. These contractions provide the required force to expel the fetus from the uterus. The inclusion of these physiological processes is, therefore, imperative when studying uterine contractions. In this study, an electro-chemo-mechanical model to replicate the excitation, activation, and contraction of uterine smooth muscle cells is developed. The presented modeling strategy enables efficient integration of knowledge about physiological processes at the cellular level to the organ level. The model is implemented in a three-dimensional finite element setting to simulate uterus contraction during labor in response to electrical discharges generated by pacemaker cells and propagated within the myometrium via gap junctions. Important clinical factors, such as uterine electrical activity and intrauterine pressure, are predicted using this simulation. The predictions are in agreement with clinically measured data reported in the literature. A parameter study is also carried out to investigate the impact of physiologically related parameters on the uterine contractility. |
| Databáze: | OpenAIRE |
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