Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer
| Autor: | Anđelka Radojčić Badovinac, Darian Volarić, Sanja Dević Pavlić, Miljenko Kapović, Smiljana Ristić, Veljko Flego, Sergej Nadalin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty insertion/deletion polymorphism General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics Genomics and Proteomics Internal medicine Renin–angiotensin system medicine General Pharmacology Toxicology and Pharmaceutics Allele Lung cancer nicotine dependence Genotyping BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina Oncogene business.industry General Neuroscience angiotensin‑converting enzyme gene lung cancer General Medicine Odds ratio Articles medicine.disease Angiotensin II Molecular medicine 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis business BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika genomika i proteomika čovjeka |
| Zdroj: | Biomedical Reports Volume 13 Issue 6 Biomed Rep |
| ISSN: | 2049-9434 2049-9442 |
| DOI: | 10.3892/br.2020.1365 |
| Popis: | The biologically active peptide angiotensin II is cleaved from angiotensinogen by the renin and the angiotensin‑converting enzyme (ACE), an enzymatic cascade known as the renin‑angiotensin system (RAS). RAS may be important in the etiology of nicotine dependence by influencing dopaminergic signaling. In the present study, the association between an insertion/deletion (I/D) polymorphism of ACE and nicotine dependence amongst patients with lung cancer was assessed. To date, several studies have shown the relevance of this polymorphic variant in both nicotine dependence and lung cancer. However, the present study is the first to address the potential role of the ACE‑I/D polymorphism in nicotine dependence among patients with lung cancer. Genotyping was performed in 305 patients with lung cancer (males/females, 214/91). Significantly more male smokers had the ACE‑I allele compared with male non‑smokers (44.9 vs. 20.0% ; P |
| Databáze: | OpenAIRE |
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