Prevalence of fat redistribution and metabolic disorders in human immunodeficiency virus-infected children
| Autor: | María Jesús García-Miguel, Raquel Munoz Muniz, Maria Gomez, Ana Torres, Rosario Madero, C Borque |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Population Hypercholesterolemia HIV Infections Acquired immunodeficiency syndrome (AIDS) Internal medicine Antiretroviral Therapy Highly Active medicine Prevalence Humans Family history education Child Lipoatrophy Hypertriglyceridemia education.field_of_study business.industry HIV-Associated Lipodystrophy Syndrome Metabolic disorder Age Factors Lipohypertrophy Infant medicine.disease Cross-Sectional Studies Anti-Retroviral Agents Child Preschool Pediatrics Perinatology and Child Health Immunology Female Lipodystrophy business Viral load |
| Zdroj: | European journal of pediatrics. 164(5) |
| ISSN: | 0340-6199 |
| Popis: | In this study we assessed the prevalence of fat redistribution and metabolic disorders in a population of HIV-infected children on antiretroviral treatment. To make associations with epidemiological parameters, clinical-immune status, viral load and highly active antiretroviral therapy (HAART), we performed a cross-sectional study in HIV-infected children. Epidemiological parameters (age, sex, family history), clinical and immune status, viral load, and duration of antiretroviral treatment (ART) and HAART, including protease inhibitors, were recorded. Presence of clinical signs of fat redistribution and lipid, glucose and lactic acid levels were evaluated. A total of 56 HIV-infected children, including 30 boys (54%), aged between 21 months and 18 years (mean 9.5 years) were studied. In all, 49 patients (87.5%) were receiving ART (mean duration 4 years) and 43 (77%) were receiving HAART (mean duration 3.6 years). Fat redistribution or lipodystrophy was present in 14 patients (25%); seven had lipohypertrophy (12.5%), two lipoatrophy (3.5%) and five a mixed pattern (8.9%). Fat redistribution was higher in children older than 11 years (50%). Of the lipodystrophic patients, 71.4% presented hypertriglyceridaemia (>130 mg/dl) and 57% hypercholesterolaemia (>180 mg/dl). We found significant associations between lipodystrophy and age, ART and HAART duration and hypertriglyceridaemia ( P |
| Databáze: | OpenAIRE |
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