What is known about melatonin, chemotherapy and altered gene expression in breast cancer
| Autor: | Carolina Alonso González, Javier Menéndez Menéndez, Alicia González, Samuel Cos, Virginia Álvarez‑García, Carlos Manuel Martínez Campa |
|---|---|
| Přispěvatelé: | Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research endocrine system medicine.medical_treatment melatonin Review Biology chemotherapy Melatonin 03 medical and health sciences Pineal gland 0302 clinical medicine Breast cancer breast cancer medicine cancer Chemotherapy Oncogene Cancer medicine.disease Molecular medicine Radiation therapy 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research gene expression hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Oncology Letters Oncol Lett. 2017 Apr;13(4):2003-2014 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Melatonin, synthesized in and released from the pineal gland, has been demonstrated by multiple in vivo and in vitro studies to have an oncostatic role in hormone?dependent tumors. Furthermore, several clinical trials point to melatonin as a promising adjuvant molecule to be considered for cancer treatment. In the past few years, evidence of a broader spectrum of action of melatonin as an antitumor agent has arisen; thus, melatonin appears to also have therapeutic effects in several types of hormone?independent cancer, including ovarian, leukemic, pancreatic, gastric and non?small cell lung carcinoma. In the present study, the latest findings regarding melatonin molecular actions when concomitantly administered with either radiotherapy or chemotherapy in cancer were reviewed, with a particular focus on hormone?dependent breast cancer. Finally, the present study discusses which direction should be followed in the next years to definitely clarify whether or not melatonin administration could protect against non?desirable effects (such as altered gene expression and post?translational protein modifications) caused by chemotherapy or radiotherapy treatments. As treatments move towards personalized medicine, comparative gene expression profiling with and without melatonin may be a powerful tool to better understand the antitumor effects of melatonin, the pineal gland hormone. |
| Databáze: | OpenAIRE |
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