Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis
| Autor: | Masaru Ishii, Atsushi Tamura, Hirofumi Miyata, Ichiro Katayama, Masato Ohmi, Sachiko Tsukita, Kosuke Yamaga, Hiroyuki Murota, Junichi Kikuta |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty endocrine system diseases Sweating Dermatology urologic and male genital diseases digestive system Biochemistry Dermatitis Atopic Tight Junctions SWEAT Pathogenesis 03 medical and health sciences Mice Young Adult Internal medicine Sweat gland medicine Animals Claudin-3 Humans Claudin Sweat Molecular Biology Mice Knockout integumentary system Tight junction Chemistry CLDN3 Cell Biology Atopic dermatitis medicine.disease Water Loss Insensible digestive system diseases Acetylcholine Healthy Volunteers Sweat Glands Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology Female Homeostasis |
| Zdroj: | The Journal of investigative dermatology. 138(6) |
| ISSN: | 1523-1747 |
| Popis: | The transfer of sweat to the skin surface without leakage is important for the homeostatic regulation of skin and is impaired in atopic dermatitis. Although the precise composition of the leakage barrier remains obscure, there is a large contribution from claudins, the major components of tight junctions. In humans, claudin-1, -3, and -15 are expressed on sweat ducts, and claudin-3 and -10 are expressed on secretory coils. Although only two claudins are expressed in murine sweat glands, we found that the expression of claudin-3 is conserved. Atopic dermatitis lesional skin had decreased claudin-3 expression in sweat glands, which was accompanied by sweat leakage. This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3. Our results show the crucial role of claudin-3 in preventing sweat gland leakage and suggest that the pathogenesis of dermatoses accompanied by hypohidrosis involves abnormally decreased claudin-3. |
| Databáze: | OpenAIRE |
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