Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract
| Autor: | Priya Walwatkar, Zubair M. Affandi, Hemant S. Paradkar, Sujata Jagtap, P H Paradkar, Ashok D.B. Vaidya, Jayashree V Joshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Papanicolaou stain Lesion 03 medical and health sciences 0302 clinical medicine Internal medicine Cytology Drug Discovery Original Research Article (Clinical) Atypia medicine lcsh:Miscellaneous systems and treatments Cervical cancer Colposcopy Gynecology medicine.diagnostic_test business.industry Therapeutic effect Cancer Turmeric lcsh:RZ409.7-999 medicine.disease Integrated treatment female genital diseases and pregnancy complications 3. Good health 030104 developmental biology Complementary and alternative medicine 030220 oncology & carcinogenesis Pap smear medicine.symptom business |
| Zdroj: | Journal of Ayurveda and Integrative Medicine Journal of Ayurveda and Integrative Medicine, Vol 7, Iss 2, Pp 109-112 (2016) |
| ISSN: | 0976-2809 0975-9476 |
| Popis: | Cervical cancer is preventable because the carcinogenesis is slow and there are opportunities to detect precancerous lesions by Papanicolaou (Pap) smears, colposcopy, or HPV DNA tests and to treat them by antimicrobials, surgery or cold CO 2 vapourization. We have earlier reported on the chemopreventive potential of integrated treatment with antimicrobials therapy followed by a standardized oral Turmeric Oil (TO) extract upto 12 weeks in women who had persistent Low-grade Squamous Intra-epithelial Lesion (LSIL) in their Pap smears. In this communication we report their post-therapy follow up for 36 months (N = 18) with Pap smears. We were also able to follow up for 36 months control cases (N = 10) who had only standard therapy with antimicrobials. During 36 months of follow up none of the cases with integrated treatment, progressed to HSIL or cancer. Out of 15/18 cases which had a regression of Pap smear, all 15 remained free of LSIL from 6 to 36 months post-therapy showing persistent therapeutic effect of integrated therapy. In one case there was recurrence of LSIL in Pap smear, ten months post-therapy, which regressed to mild atypia after a second course of oral TO for 8 weeks. In the control group, persistence of LSIL after antimicrobials was observed in Pap smears in 5/10 cases when followed up by Pap smears up to 36 months. This preliminary report indicates some post-therapeutic benefit with integrative treatment as compared to the use of antimicrobials alone. A large scale controlled study is warranted. |
| Databáze: | OpenAIRE |
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