Association between retinal vascular caliber and brain structure in schizophrenia
| Autor: | Dona Maria Chako, Ananth Padmanabha, Abhishek Appaji, Umesh Thonse, Bhargavi Nagendra, Rose Dawn Bharath, Vijay Kumar, Arpitha Jacob, Naren P. Rao, Vittal Korann, Shivarama Varambally, Shyam Vasudeva Rao, Ganesan Venkatasubramanian, Tos T. J. M. Berendschot, Carroll A.B. Webers, Priyanka Devi |
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| Přispěvatelé: | MUMC+: *MA Oogheelkunde (3), Oogheelkunde, MUMC+: University Eye Center Maastricht (3), MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R3 - Neuroscience, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Medical Image Analysis |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Psychosis
medicine.medical_specialty Neurodevelopment behavioral disciplines and activities 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Humans fundus photography NETWORK General Psychology Cerebral Cortex Retina medicine.diagnostic_test business.industry Fundus photography Brain Retinal Magnetic resonance imaging General Medicine Biomarker Schizophrenia/diagnostic imaging Brain/diagnostic imaging medicine.disease Magnetic Resonance Imaging Frontal Lobe 030227 psychiatry Psychiatry and Mental health Structural MRI medicine.anatomical_structure chemistry Schizophrenia Caliber Brain size business 030217 neurology & neurosurgery |
| Zdroj: | Asian Journal of Psychiatry, 61:102707. Elsevier Science Asian Journal of Psychiatry, 61:102707. Elsevier |
| ISSN: | 1876-2018 |
| Popis: | ObjectiveSeveral lines of research in the last decade have indicated the potential utility of retina as a window to the brain. Emerging evidence suggests abnormalities in retinal vascular caliber in schizophrenia. However, the relationship between retinal vascular measures and brain structure has not been examined in schizophrenia to date. Hence, we examined the relationship between retinal vasculature measured using fundus photography and brain structure measured using magnetic resonance imaging.MethodWe recruited 17 healthy volunteers and 20 patients with schizophrenia. Using a non-mydriatic camera, we captured the images for left and right eyes separately and retinal vascular calibers were calculated using a semi-automated software package. Whole-brain anatomical T1 MPRAGE images were acquired using a 3-Tesla MRI scanner. Whole-brain and regional volume and cortical thickness were calculated using the Freesurfer software package. We used FreeSurfer’s QDEC interface to compute vertex-by-vertex for analysis of the volume and cortical thickness. The relation between brain volume, cortical thickness, and retinal vascular caliber was examined using partial correlation and regression analysis.ResultsThere was a significant negative correlation between average CRVE and global cortical mean thickness in schizophrenia but not in healthy. In schizophrenia patients, there was a significant negative correlation between average CRVE and cortical thickness in frontal regions – left rostral middle frontal, left superior frontal, and right caudal middle frontal gyri and posterior brain regions – left lateral occipital gyrus and left posterior cingulate cortex.DiscussionThe findings of the study suggest potential utility of retinal venular diameter as a proxy marker to abnormal neurodevelopment in schizophrenia. |
| Databáze: | OpenAIRE |
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