Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
| Autor: | Alissar El Chediak, Ali Shamseddine, Sarah Abdel Massih, Raafat Alameddine, Lara Hilal, Maya Charafeddine, Sally Temraz, Deborah Mukherji, Lana Hamieh, Ayman Hakim |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis disease-free survival early Breast cancer Internal medicine Medicine Risk factor Stage (cooking) Prospective cohort study Original Research Gynecology biology business.industry young subtypes Retrospective cohort study Targets and Therapy [Breast Cancer] medicine.disease worse prognosis Oncology risk factor Methylenetetrahydrofolate reductase Cohort biology.protein business |
| Zdroj: | Breast Cancer : Targets and Therapy |
| ISSN: | 1179-1314 |
| Popis: | Alissar El Chediak,1 Raafat S Alameddine,1 Ayman Hakim,1 Lara Hilal,2 Sarah Abdel Massih,1 Lana Hamieh,3 Deborah Mukherji,1 Sally Temraz,1 Maya Charafeddine,1 Ali Shamseddine1 1Division of Hematology/Oncology, Department of Internal Medicine, 2Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon; 3Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA Background: Several retrospective studies have reported that younger age at presentation is associated with a worse prognosis for nonmetastatic breast cancer patients. In this study, we prospectively assessed the association between different baseline characteristics (age, tumor characteristics, mode of treatment, etc) and outcomes among newly diagnosed nonmetastatic Lebanese breast cancer patients.Methods: We recruited a sample of 123 women newly diagnosed with nonmetastatic breast cancer presenting to American University of Beirut Medical Center. Immunohistochemical, molecular (vitamin D receptor, methylene tetrahydrofolate reductase polymorphisms), and genetic assays were performed. Patient characteristics were compared by age group (40 years (5.2%). A wide immunohistochemical panel included Ki-67, cyclin B1, p53, platelet-derived growth factor receptor, and vascular endothelial growth factor receptor, and did not reveal any significant difference in these markers between the two age groups. Older patients had a larger percentage of Luminal A than younger patients. On multivariate analysis including age, stage, grade, and subtype, only age 40 years was 90%, and for patients |
| Databáze: | OpenAIRE |
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