Cardiovascular‐specific PSEN1 deletion leads to abnormalities in calcium homeostasis

Autor: Xiao‐Wei Song, Feng Zhao, Jing Yang, Qing‐Ning Yuan, Zhen‐Yu Zeng, Ming Shen, Ying Tang, Mi Cao, Ya‐Feng Shen, Song‐Hua Li, Yong‐Ji Yang, Hong Wu, Xian‐Xian Zhao, Shu‐Ting Hu
Rok vydání: 2022
Předmět:
Zdroj: Cell Biology International. 46:475-487
ISSN: 1095-8355
1065-6995
DOI: 10.1002/cbin.11753
Popis: Mutations of PSEN1 have been reported in dilated cardiomyopathy pedigrees. Understanding the effects and mechanisms of PSEN1 in cardiomyocytes might have important implications for treatment of heart diseases. Here, we showed that PSEN1 was downregulated in ischemia-induced failing hearts. Functionally, cardiovascular specific PSEN1 deletion led to spontaneous death of the mice due to cardiomyopathy. At the age of 11 months, the ratio of the heart weight/body weight was slightly lower in the Sm22a-PSEN1-KO mice compared with that of the WT mice. Echocardiography showed that the percentage of ejection fraction and fractional shortening was significantly reduced in the Sm22a-PSEN1-KO group compared with the percent of these measures in the WT group, indicating that PSEN1-KO resulted in heart failure. The abnormally regulated genes resulted from PSEN1-KO were detected to be enriched in muscle development and dilated cardiomyopathy. Among them, several genes encode Ca
Databáze: OpenAIRE
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