Borna disease virus and psychiatry
| Autor: | O. Taieb, A. M. Fillet, P. Mazet, J. M. Baleyte |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Psychosis
medicine.medical_specialty Bipolar Disorder animal diseases viruses Central nervous system Disease Biology Virus Central nervous system disease 03 medical and health sciences 0302 clinical medicine medicine Humans Autistic Disorder Borna disease virus Mononegavirales Psychiatry Brain RNA virus biology.organism_classification medicine.disease 030227 psychiatry Developmental disorder Psychiatry and Mental health medicine.anatomical_structure Borna Disease Immunology Schizophrenia RNA Viral 030217 neurology & neurosurgery |
| Zdroj: | European Psychiatry. 16:3-10 |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) disease with various manifestations, depending on both host and viral factors. In animal infections, BDV can persist in the CNS and induce alterations in brain cell functions, neurodevelopmental abnormalities and behavioral disturbances. An association between BDV and psychiatric disorders (essentially schizophrenia and affective disorders) has been suggested by some serologic and molecular studies but further investigations are required to substantiate the possible contribution of this virus to the pathogenesis of these disorders. |
| Databáze: | OpenAIRE |
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