What Is the Safe Approach for Neonatal Hypernatremic Dehydration? A Retrospective Study From a Neonatal Intensive Care Unit
| Autor: | Füsun Dilara Içağasoğlu, Demet Alaygut, Ömer Cevit, Göktuğ Özdemir, Ahmet Sami Güven, Melih Timucin Dogan, Fatih Bolat, Mehmet Burhan Oflaz, Asım Gültekin |
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| Přispěvatelé: | [Bolat, Fatih -- Gultekin, Asim] Cumhuriyet Univ, Fac Med, Dept Neonatol, TR-58140 Sivas, Turkey -- [Oflaz, Mehmet Burhan -- Guven, Ahmet Sami -- Ozdemir, Goktug -- Alaygut, Demet -- Dogan, Melih Timucin -- Icagastoglu, Fusun Dilara -- Cevit, Omer] Cumhuriyet Univ, Fac Med, TR-58140 Sivas, Turkey, Oflaz, Mehmet Burhan -- 0000-0003-1515-4654 |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neonatal intensive care unit hypernatremic dehydration Critical Care Fever Turkey Hypernatremic Dehydration complications Developmental Disabilities Brain Edema Hospital mortality Seizures Intensive Care Units Neonatal Weight Loss medicine Humans term neonates Hospital Mortality Infusions Intravenous Retrospective Studies Hypernatremia Dehydration business.industry Osmolar Concentration Sodium Infant Newborn Retrospective cohort study General Medicine Acute Kidney Injury Sodium blood Combined Modality Therapy Breast Feeding Rehydration Solutions Pediatrics Perinatology and Child Health Emergency Medicine Fluid Therapy Brain Damage Chronic Female Acidosis business Intracranial Hemorrhages Breast feeding management |
| ISSN: | 2382-3259 |
| Popis: | WOS: 000330470200007 PubMed ID: 23823259 Objectives: The aims of this study were to evaluate the prevalence, complications, and mortality of hypernatremic dehydration in neonates and to compare the effect of correction rate at 48 hours on mortality and on neurological outcome in the short term. Methods: This retrospective study was conducted between January 2007 and 2011 in the neonatal intensive care unit. Term neonates were included. The wpatients were grouped as follows: group 1 = 150 to 160 mmol/L, group 2 = 161 to 170 mmol/L and group 3 = 171 to 189 mmol/L. Results: Among 4280 neonates, 81 cases (1.8%) had hypernatremic dehydration. Groups 1, 2, and 3 consisted of 55, 23, and 3 patients, respectively. Mortality rates were as follows: 3.6%, 17.3%, and 66.6%. Mean serum sodium (Na) correction rates at 0 to 24 hours and 24 to 48 hours were 0.48 +/- 0.2 versus 0.38 +/- 0.31 mmol/L per hour (group 1) and 0.49 +/- 0.21 versus 0.52 +/- 0.28 mmol/L per hour (group 2), respectively. In 32 patients (58.1%) from group 1 and in 13 patients (56.5%) from group 2, correction rate of 0.5 mmol/L per hour or less was achieved. Twenty-two patients developed convulsions, which was the most common complication during therapy. Serum Na greater than 160 mmol/L at admission (odds ratio, 1.9; 95% confidence interval, 1.3-3.7) and serum Na correction rate of greater than 0.5 mmol/L per hour (odds ratio, 4.3; 95% confidence interval, 1.2-6.5) were independent risk factors for death or convulsion. There was a significant difference between groups 1 and 2 in Denver Developmental Screening Test II results (64.1% vs 30.7 %, P = 0.001). Conclusion: Hypernatremic dehydration is an important problem that should be managed properly to avoid adverse outcomes. |
| Databáze: | OpenAIRE |
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