The influence of an atherogenic, semisynthetic diet on cholesterol metabolism in rabbits
| Autor: | Walter Mlekusch, B. Paletta, Karoline Vrecko |
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| Rok vydání: | 1980 |
| Předmět: |
Cocos
Male medicine.medical_specialty Duodenum Hypercholesterolemia Hepatic cholesterol Blood lipids Aorta Thoracic Methylcellulose Biology Zea mays chemistry.chemical_compound Biosynthesis Intestinal mucosa Internal medicine medicine.artery medicine Animals Cholesterol metabolism Intestinal Mucosa Aorta Cholesterol Reverse cholesterol transport Caseins Starch Animal Feed Endocrinology Liver chemistry Diet Atherogenic lipids (amino acids peptides and proteins) Rabbits Soybeans Cardiology and Cardiovascular Medicine Oils |
| Zdroj: | Atherosclerosis. 37:371-375 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(80)90141-0 |
| Popis: | The influence of a cholesterol-free, semisynthetic diet on the cholesterol content and on the incorporation of radioacetate into cholesterol in liver, aorta and intestinal mucosa of the rabbit was tested over periods of 3 and 6 months. The incorporation of radioacetate in the liver reached a maximum after 3 months. In contrast to this, the rate of acetate incorporation in the aorta and mucosa continued to rise throughout the entire test period. The cholesterol level in serum ran parallel to the hepatic cholesterol synthesis reaching a maximum after 3 months. While the cholesterol content of the liver remained unchanged, it rose in the aorta and mucosa. These results favour the assumption that hypercholesterolemia was not due to a defect in removal of cholesterol from the plasma compartment, but to an increased biosynthesis. |
| Databáze: | OpenAIRE |
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