Experimental treatment of cutaneous leishmaniasis with argentilactone isolated from Annona haematantha
| Autor: | Hector Nakayama, Adrien Cave, Alain Fournet, M. E. Ferreira, Susana Torres, A. Rojas de Arias, R. Hocquemiller, A.‐I. Waechter |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Leishmania mexicana Pharmaceutical Science Leishmaniasis Cutaneous Spleen Pharmacology Pharmacognosy Analytical Chemistry Lactones Mice Cutaneous leishmaniasis In vivo Oral administration Drug Discovery medicine Animals Medicine African Traditional Mice Inbred BALB C Plants Medicinal biology Organic Chemistry Leishmaniasis medicine.disease biology.organism_classification Leishmania Trypanocidal Agents French Guiana medicine.anatomical_structure Complementary and alternative medicine Immunology Molecular Medicine Female Annona |
| Zdroj: | Planta medica. 63(5) |
| ISSN: | 0032-0943 |
| Popis: | From the hexanic extract of roots of Annona haematantha an alpha,beta-unsaturated delta-lactone was isolated and identified as argentilactone. This compound exhibited in vitro activity against various strains of Leishmania ssp. at 10 micrograms/ml. BALB/c mice infected with Leishmania amazonensis were treated four weeks after infection with argentilactone by oral or subcutaneous routes for 14 days at 25 mg/kg daily. The reference drug, N-methylglucamine antimonate, was administered by subcutaneous injections at 100 mg/kg for 14 days. In these conditions, argentilactone showed the same efficacy as the reference drug, reducing by 96% the parasite loads in the lesion and by 50% the parasite burden in spleen. |
| Databáze: | OpenAIRE |
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