Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly
| Autor: | Jingping Tang, Jing Zeng, Yao He, Miao Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging China medicine.medical_specialty Endocrinology Diabetes and Metabolism Serum Albumin Human 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Weight Gain Body Mass Index Cohort Studies Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Weight Loss Internal Medicine medicine Humans Aged Proportional Hazards Models Retrospective Studies Veterans Aged 80 and over business.industry Incidence Incidence (epidemiology) Hazard ratio Middle Aged medicine.disease Impaired fasting glucose Confidence interval Up-Regulation Military Personnel Diabetes Mellitus Type 2 Elder Nutritional Physiological Phenomena business Body mass index Biomarkers Follow-Up Studies Cohort study |
| Zdroj: | Journal of Diabetes and its Complications. 31:1663-1668 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2017.08.015 |
| Popis: | Aims Albumin (ALB) was a useful marker of nutrition and general health status. However, the conclusion about the association between ALB and diabetes was inconsistent, and little information was known about the elderly. Methods A cohort study based on 18,384 army cadres was conducted Beijing, from 2009 to 2013. Results The mean age of the total 18,384 participants was 71±14years, and the mean ALB concentration was 44.33±3.94g/L at baseline. Diabetes incident showed an increasing trend according to the four ALB concentration groups, from 2.054% to 2.811% for incident. Cox regression showed that participants with higher ALB concentration were at increased HRs for diabetes incident. The HRs of ALB (per SD) and ALB concentration for diabetes were 1.125 (95% CI: 1.024–1.231) and 1.029 (95% CI: 1.007–1.051) respectively in the adjusted model. Also the HRs were closely related with BMI changes. For those who had a BMI changes 2 , the HRs were lower and not statistically significant, and for those with increasing BMI during an average of 4years' follow-up, the HRs were higher. Conclusion There was a positive and independent association between baseline ALB concentrations with diabetes incident among Chinese male elderly, and this association was closely related with BMI changes. |
| Databáze: | OpenAIRE |
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