An Investigation of Micro-CT Analysis of Bone as a New Diagnostic Method for Paleopathological Cases of Osteomalacia
| Autor: | A.E. van der Merwe, Andrew J. Nelson, H. Welsh, H.H. de Boer, Megan Brickley |
|---|---|
| Přispěvatelé: | Medical Biology |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Archeology medicine.medical_specialty Microcomputed Tomography Diagnostic methods Adolescent Cement line Paleopathology Active rickets Bone and Bones vitamin D deficiency Pathology and Forensic Medicine Young Adult medicine Humans Vitamin D Micro ct Osteomalacia Microscopy Health consequences business.industry X-Ray Microtomography Vitamin D Deficiency medicine.disease Metabolic Disease Anthropology Female Radiology business Bioarchaeology |
| Zdroj: | Anthropology Publications INTERNATIONAL JOURNAL OF PALEOPATHOLOGY, 31, 23-33. Elsevier BV |
| ISSN: | 1879-9817 |
| Popis: | Objective This paper looks to broaden the methodological possibilities for diagnosing osteomalacia in archaeological bone using micro-CT analysis. Increasing the identification of osteomalacia in paleopathology will provide support for important interpretive frameworks. Materials Nine embedded and two unembedded rib fragments were sourced from St. Martin’s Birmingham and Ancaster, UK, and Lisieux Michelet, France. Of the 11 samples, nine were previously confirmed as osteomalacic, and presented with varying levels of diagenesis and two were non-osteomalacic controls, one of which exhibits diagenetic change. Methods Micro-CT, backscattered scanning electron microscopy, and light microscopy were employed. Micro-CT images were evaluated for osteomalacic features using corresponding microscopic images. Results Micro-CT images from osteomalacic samples demonstrated the presence of defective mineralization adjacent to cement lines, areas of incomplete mineralization, and resorptive bays/borders, three key diagnostic features of osteomalacia. Diagenetic change was also detectable in micro-CT images, but did not prevent the diagnosis of osteomalacia. Conclusions Micro-CT analysis is a non-destructive method capable of providing microstructural images of osteomalacic features in embedded and unembedded samples. When enough of these features are present, micro-CT images are capable of confirming a diagnosis of osteomalacia. Significance Vitamin D deficiency has important health consequences which operate throughout the life course. Increasing the ability to detect cases of vitamin D deficiency provides researchers with a greater understanding of health and disease in past communities. Limitations Only adult rib samples were used. Suggestions for further research Paleopathologists should look to test the utility of micro-CT analysis in diagnosing active rickets in subadult individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect