Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
| Autor: | Esther T. Stoeckli, Nikole R. Zuñiga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
animal structures Synaptogenesis Biology 03 medical and health sciences 0302 clinical medicine Precursor cell medicine Sonic hedgehog Molecular Biology lcsh:QH301-705.5 midline crossing synaptogenesis axon guidance Wnt signaling pathway Cell Biology Commissure Spinal cord commissural axons 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) embryonic structures biology.protein Axon guidance Neuroscience 030217 neurology & neurosurgery Developmental Biology Morphogen |
| Zdroj: | Journal of Developmental Biology, Vol 5, Iss 1, p 2 (2017) |
| ISSN: | 2221-3759 |
| Popis: | As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural circuit formation. Both in vitro and in vivo studies indicated that morphogens direct axons during their navigation through the developing nervous system. Today, the best understood role of Shh and Wnt in axon guidance is their effect on commissural axons in the spinal cord. Shh was shown to affect commissural axons both directly and indirectly via its effect on Wnt signaling. In fact, throughout neural circuit formation there is cross-talk and collaboration of Shh and Wnt signaling. Thus, although the focus of this review is on the role of Shh in neural circuit formation, a separation from Wnt signaling is not possible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|